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Table 2.

Human Genes with Two or More Zebrafish Orthologs

Human gene	Reference (NCVI unigene)	Human map position	Zebrafish ortholog	Reference (NCBI gi)	Zebrafish map position
HES5	no ref	1.49-52cM[ii]	her2	1279391	8.472cR[iv]
			her4	1279395	23.99cR[iv]
HFH2	Hs.166188	1.95-102cM	fkd8	2982352	8.299cR[v]
			fkd6	2982348	6.273cR[iii]
SOX11	Hs.32964	2.0-32cM	sox11a	NA	17.234cR[v]
			sox11b	NA	20.499cR[v]
RARA	Hs.173205	2.51-54cM	rara2a	704369	12.125cR[iv]
			rara2b	215025	3.161cR[v]
SIX3	Hs.227277	2.73-88cM	six6	3047418	12.188cR[vii]
			six3	304716	13.278cR[vii]
EN1	II.2019	2.127-134cM	eng4	4322043	1.59cR[v]
			eng1	62515	9.9cR[v]
DLX2	Hs.419	2.182-188cM	dlx5	1620515	1.179cR[iv]
			dlx2	460126	9.131cR[iv]
IHH	Hs.69351	2.200-215cM	ehh	1616584	6.115cR[v]
			hha	NA	9.140cR[v]
FZD5	Hs.152251	2.211-218	fz8a	4164470	24.133cR[vii]
			frz-zg06	1245193	2.438cR[vii]
FZD7	Hs.173859	2.200-206cM	frz-zg07	1245195	9.170cR[vii]
			fb38g02		6.115cR[iii]
			frz-zg13	1245207	6.129cR[vii]
GATA2	Hs.760	3.142-146cM	gata1	1132418	11.230cR[v]
			gata2	1132420	11.390cR[iv]
ATP1B3	Hs.76941	3.157-158cM	atp1b	974773	2.150cR[vii]
			fb13c07		15.57cR[ii]
EPHA5	Hs.31092	4.68-78cM	fb82e05		24.301cR[iii]
			rtk7	3005904	24.301cR[iii]
NPY1R	Hs.169266	4.157-169cM	zya	3098345	17.79cR[v]
			zyb	2739140	8.563cR[v]
			zyc	3098347	10.385cR[v]
EFNA5	Hs.37142	5.108-116cM	al1	1834430	8.10cR[iv]
			ephra5	2462952	21.129cR[iii]
CSX	Hs.54473	5.161-163cM	nkx2.7	1518150	8.505cR[vi]
			nkx2.5	1518148	14.341cR[v]
MSX2	Hs.89404	5.185-196cM	msxe	1399516	14.27cR[iv]
			msxa	608508	14.464cR[v]
			msxd	62544	21.211cR[iv]
ISL1	Hs.505	5.54-61cM	islet1	497897	5.143cR[iv]
			islet2	1037165	25.406cR[iv]
			islet3	1037167	25.406cR[vii]
AHR	Hs.170087	7.24-35cM	ahr2	4321818	22.88cR[vii]
			ahr	2764987	16.196cR[iii]
EVX1	Hs.99967	7.38-42cM	eve1	475049	3.113cR[iv]
			evx1	no ref.	16.175cR[v]
HOXA	N/A	7.39-40cM	hoxa13b	4322052	16.175cR[v]
			hoxa4a	4322059	19.170cR[iv]
EN2	Hs.134989	7.167-175cM	eng2	62517	7.158cR[iv]
			eng3	62521	2.343cR[iv]
SHH	Hs.121539	7.181-184cM	shh	5714439	7.158cR[iv]
			twhh	1171139	2.346cR[v]
SLUG	Hs.93005	8.57-68cM	sna2	841423	23.41cR[v]
			sna1	468620	11.284cR[iv]
NOTCH1	II.4851	9.136-148cM	notch1b	2569967	5.267cR[vii]
			notch1	433866	21.75cR[vii]
RXRA	Hs.20084	9.143-166cM	rxrg	1046288	5.222cR[vii]
			rxra	1046294	2.309cR[iv]
FTH1	Hs.62954	11.16-23cM	fb06g09		7.45cR[iii]
			fb01e08		24.144cR[iii]
WNT11	Hs.108219	11.80-84cM	wnt11	3169686	5.125cR[vi]
			wnt11r	NA	10.306cR[v]
HSPA10	Hs.180414	11.128-132cM	hsc70.1	1408566	3.113cR[v]
			fb01g06		10.304cR[iii]
SPON1	Hs.5378	11.24-25cM	fspdin2	2529226	25.70cR[vii]
			mindin1	2529220	14.379cR[vii]
			mindin2	2529222	14.341cR[vii]
HOXC	N/A	12.70-72cM	hoxc5a	414104	23.324cR[iv]
			hoxc13b	4322091	11.459cR[v]
ASCL1	Hs.1619	12.106-113cM	zasha	540237	4.149cR[iv]
			zashb	540239	7.177cR[iv]
OTX2	II.5015	14.0-1cM	otx2	540243	17.304cR[iii]
			otx3	633134	1.381cR[iv]
RTN1	Hs.99947	14.54-58cM	deltab	2772824	5.125cR[v]
			dla	2809388	1.395cR[v]
HOXB	N/A	17.62-69cM	hoxb4a	341108	3.113cR[vii]
			hoxb1b	1127809	12.188cR[iv]
LHX1	Hs.157449	17.58-63cM	lim1	577524	15.189cR[v]
			lim6	2155288	5.171cR[v]
NOTCH3	Hs.8546	19.42-45cM	notch3	3153196	3.430cR[vii]
			notch5	2569969	3.430cR[vii]
PR65	Hs.173902	19.59-98cM	fa02h04		5.171cR[vii]
			fb38a08		15.138cR[iii]
CKM	Hs.118843	19.59-98cM	fa28d05		5.125cR[vii]
			fc14g11		13.183cR[iii]
MYRL2	Hs.9615	19.59-98cM	fa93e09		7.284cR[iii]
			fa97a12		2.340cR[iii]
BMP2	Hs.73853	20.18-27cM	bmp2	2804174	20.678cR[iv]
			bmp2a	2149147	17.43cR[v]
SNAP25	Hs.84389	20.27-37cM	snap25a	3703097	20.459cR[iv]
			snap25b	3703099	17.79cR[iv]
L1CAM	Hs.1757	X.188-198cM	nadl1.1	1065713	23.22cR[iv]
			nadl1.2	1065715	23.163cR[iv]

[i] Orthologs predicted with aid of syntenic correspondence (see Table3) are shown in bold.

[ii] Position for human gene is inferred from map position of orthologous mouse gene and the mouse–human syntenic relationship (DeBry and Seldin 1996).

[iii] Genes and ESTs mapped in this study.

[iv] Hukriede et al. 1999.

[v] Postlethwait et al. 1998, Amores et al. 1998.

[vi] Gates et al. 1999.

[vii] Geissler et al. 1999.