Obese Maternal Environment Contributes to Diabetogenic Thresholds
| Dam | n | BW (g) 4 wk | BW (g) 24 wk | PI (ng/mL) 16 wk | PG (mg/dL) 24 wk | BMI 24 wk | AI 24 wk | Leptin (ng/mL) 24 wk |
| F1 (obese) | 89 | 23.4 ± 0.4 | 53.7 ± 0.7 | 10.3 ± 1.0 | 282 ± 14 | .422 ± .004 | 13.4 ± .25 | 51.1 ± 2.0 |
| NON (lean) | 114 | 21.5 ± 0.3 | 48.8 ± 0.6 | 6.1 ± 0.7 | 208 ± 7 | .393 ± .004 | 12.4 ± .20 | 41.8 ± 2.0 |
[i] (BW) body weight; (PI) plasma insulin; (PG) plasma glucose; (BMI) body mass index; (AI) adiposity index.
[ii] Values are mean ± SEM. Differences all significant at P ≤ 0.0003 except P = 0.0035 for AI and P = 0.0015 for leptin.