Table 1.

Selected Deletion Mutations

Cosmid name GenBank acc. no. Gene or protein Allele name Mutagen Deletion size (bp) Deletion effect on ORF Preliminary phenotype Reference[i]
B0478.1 U57054 Jun kinase homolognr2035DEO1825promoter–intron 7no obvious phenotype
C02B8.4 U40421 Twist transcription factor homolognr2061EMS1267Intron 1–exon 3no obvious phenotypeS. Kostas and A. Fire
C03B1.12 U40952 Lysosomal-associated membrane proteinnr2045ENU1772promoter–intron 3no obvious phenotypeD. Fambrough
C04G6.3 U55854 phospholipase D homolognr2015EMS545exon 7–exon 8no obvious phenotype
C05B5.7 Z32679 RGS GAP protein homolognr2017ENU637exon 1–intron 2mild egg-laying defectiveM. Koelle
C18E3.8 AF000265 hop-1presenilinnr2003UV-TMP1196promoter–intron 3decreased brood size at 15° C Westlund (1998)
C44H4.6 Z79598 GSK-3β kinase homolognr2056EMS1411intron 2–intron 6no obvious phenotype
C47E8.5 Z75530 daf-21 HSP90 homolognr2081ENU863exon 1–exon 4larval arrest
F02E8.6 U53340 Niemann–Pick type C protein homolognr2022EMS1120exon 3–exon 6no obvious phenotype
F10B5.4 Z48334 Tubby homolognr2044DEO1816intron 1–beyond 3′ terminusno obvious phenotype
F13B12.a Z70683 insulin homolognr2091EMS1653deletes entire ORFno obvious phenotypeS. Pierce; Gregoire et al. (1998)
F28H6.1 AL031621 akt-2kinasenr2021DEO2208promoter–exon 4no obvious phenotype
F35H12.3 U41540 sel-12presenilinnr2011ENU1426intron 2–intron 6egg-laying defect Westlund (1998)
F59G1.5 U53332 Frataxin homolognr2040DEO505promoter–intron 2no obvious phenotype
K06A1.4 U23449 nuclear hormone receptor homolognr2034ENU1189exon 3–intron 5no obvious phenotypeP. Sengupta
K06A5.7 AF039038 cdc-25homolognr2036UV-TMP2695deletes entire ORFsterile with reduced germlineA. Golden and N. Ashcroft
K06C4.6 U64843 mod-1 serotonin-gated ion channelnr2043EMS1209intron 2–exon 5resistant to serotonin-stimulated locomotionR. Ranaganathan
K06E6.1 U55375 lim-6 homeodomain proteinnr2073ENU1703exon 4–beyond 3′ terminusexpulsion defective, nose-up foraging defective, synDaf-c, axonal defects Hobert et al. (1999)
K10C3.6 Z83235 HNF4 transcription factor homolognr2041EMS893intron 2–exon 4no obvious phenotype Sluder et al. (1999)
R11A5.4 Z83122 phosphoenolpyruvate kinase homolognr2043EMS1902intron 2–exon 5no obvious phenotype
T01H8.1 Z80219 p90RSK kinase homolognr2031EMS758intron 2–exon 2no obvious phenotype
T07A9.6 AF036706 daf-18 PTEN homolognr2037UV-TMP990intron 2–exon 3dauer defective Gil et al. (1999)
T14B1.1 Z46829 tip-1novel proteinnr2084ENU1206exon 1–beyond 3′ terminusno obvious phenotypeD. Zarkower
T20H4.1 U00037 osm-10 novel proteinnr2076EMS1122intron 2–exon 5osmolarity response defective Hart et al. (1999)
Y18D10 AL008871 GSK-3β kinase homolognr2047ENU1526intron 2–beyond 3′ terminusmaternal effect early embryonic lethal
Y47D3 AL031635 p70S6 kinase homolognr2074ENU850intron 2–exon 3no obvious phenotype
Y48E1B.13 Z93393 csp-1 caspase homolognr2018UV-TMP1220exon 4–intron 5no obvious phenotypeD. Hoeppner; Shaham (1998)
ZK154.7 U70844 TNF-converting enzyme homolognr2030EMS787exon 9–intron 14no obvious phenotype
ZK520.4 Z50796 cul-2 cell cycle cullinnr2020EMS1050exon 5–exon 5embryonic arrestE. Kipreos
ZK632/6 Z22181 calnexin homolognr2010UV-TMP774exon 1–exon 3no obvious phenotype
ZK675.1 Z46812 patched homolognr2029EMS960exon 6–exon 6sterileP. Kuwabara

[i] Personal communications, unless otherwise noted.