Table 1.

Commonly Used BaseFinder Tools and Typical Parameter Values

Tool name Tool function Typical parameter values
ToolDeletePrimer2deletes all data before dye primernone
FittedBaselineAdjustremoves baseline driftwidth = 75
ToolMatrix2transforms data from spectral to dye concentrationmatrix appropriate for dye and instrument combination
ToolConvolvesmooths data to reduce noiseς = 1.5;M = 10
DeconvolutionToolimproves resolution by reducing band spreadingiterations = 5, α = 0.25, spread function polynomial based on typical data
ToolManualDeletionremoves selected regions of data, e.g., at end or beginningnone
ToolMobility3corrects polynomials for data shifts due to dye mobility differencesshift values appropriate to dye set
ToolNormalize2normalizes peak heightsnone
ToolCutoffHistoRemoves highest and lowest points from the data to improve normalizationthreshold = 2%
ToolBaseCallinglabels peaks with base-callssee text