[i] Calculation is conducted based on $750 per gigabase sequencing in January 2010 and projected cost between $70 and $110 per gigabase in January 2011. Furthermore, with the DNA capture approach, the sequencing library construction step will be reduced to a single PCR amplification step, resulting in significant savings in both cost and time. Overall, even with the projected >10-fold reduction of sequencing cost, the savings offered by capture is still very significant.