[i] The table shows all histone modifications (Barski et al. 2007) that are highly significantly (Bonferroni-corrected) enriched (or under-represented, respectively) within the identified demethylated and de novo methylated regions. Statistical analysis was performed using EpiGRAPH (here, EpiGRAPHSs overlapRegionsCount annotation was considered) (Bock et al. 2009). + indicates associated with gene activation (Barski et al. 2007); −, associated with silent genes (Barski et al. 2007); controversial, no distinct effect (Barski et al. 2007); hESCs > DE, DMRs higher methylated in hESCs compared to DE; DE > hESCs, DMRs higher methylated in DE compared with hESCs; —, not associated to DMRs; ratio control/DMRs <1, overrepresented in DMRs; and ratio control/DMRs >1 underrepresented in DMRs.