Estimates of Substitution Rates in Unconstrained Sites
| From synonymous substitutions in coding sequences | |
| 3,836 codons in CFTR Region | 1.31 subs/site |
| 1,010 codons in BRCA1 exon 11 | 2.09 subs/site |
| From extrapolation of pairwise distances in entire CFTR region | |
| 1,410,036 sites in Baboon/Human alignment | 1.50 subs/site |
| 776,169 sites in Cow/Pig alignment | 1.47 subs/site |
| 1,163,402 sites in Mouse/Rat alignment | 1.29 subs/site |
| 823,493 sites in Cat/Dog alignment | 1.32 subs/site |
| From multiple sequence alignment of CFTR region | |
| 311,741 non-exonic sites | 1.35 subs/site |