Table 1.

Gene Families Independently Duplicated in S. cerevisiae andS. pombe Encoding Proteins With Known Roles in Processes Important to the Cell Cycle (Excluding Ribosomal Proteins)

S. cerevisiae duplicates Cellular processes References
TOR1-TOR2 Cell cycle progression Powers and Walter 1999
TRK1-TRK2 Cell cycle progression, cell wall maintenance Yenush et al. 2002
PKH1-PKH2-YDR466W Actin cytoskeleton organization, cell wall maintenance Schmelze et al. 2002
ITR1-ITR2 Lipid metabolism, mating and sporulation Niederberger et al. 1998
PRK1-ARK1-AKL1 Actin cytoskeleton organization Watson et al. 2001
ROM1-ROM2 Bud formation Ozaki et al. 1996; Ni and Snyder 2001
SKN1-KRE6 Cell wall biosynthesis, bud site selection Montijn et al. 1999; Ni and Snyder 2001
SPO1-PLB1-PLB2-PLB3 Lipid metabolism, meiosis Fyrst et al. 1999
HES1-KES1 Posttranslational modification (Golgi) Li et al. 2002
SUR1-YBR161W Cell cycle progression Helliwell et al. 1998
FEN1-ELO1 Lipid metabolism, bud site selection Baudry et al. 2001; Ni and Snyder 2001
ANB1-HYP2 Protein synthesis Mehta et al. 1990
LAC1-LAG1 Posttranslational modification (Golgi) Schorling et al. 2001
GGA1-GGA2 Posttranslational modification (Golgi) Black and Pelham 2000
KTR5-KTR6 Posttranslational modification (Golgi) Lussier et al. 1999
SIM1-SUN4 Cell septation Mouassite et al. 2000
PTC2-PTC3 Cell division (DNA checkpoint) Marsolier et al. 2000
RCK1-RCK2 Inhibition of meiosis Ramne et al. 2000