Table 1.

An Overview of the Phusion Assembler Stages

Stage Brief description
Data PreparationContamination screening, vector and quality clipping.
Phusion Read GroupingReads that share low copy number words are grouped together into clusters that can be assembled independently of  each other.
RPphrapEach cluster of reads, and their associated read pairs, is assembled with PHRAP in an iterative way that allows for  contigs to be extended and broken using read pair information.
RPjoinJoins together contigs based on shared reads and sequence overlap as indicated by read pair information.
RPonoScaffolding of contigs based on read pair information.
Contamination ScreenContig and scaffold rejection based on an imbalance of read template origins.