Herpesvirus-Human Homologs
| Function class | Viral function (VIDA) | HPF[i] | Virus[ii] | GenBank[iii] | Human function |
| DNA replication | DNA polymerase | 1 | a,b,g | 8393995 | polymerase (DNA-directed), α |
| 293 | o | 15303524 | polymerase (DNA directed), δ 1 | ||
| helicase/primase | 16 | a,b,g | 5523990 | DNA helicase | |
| Nucleotide repair/ | uracil–DNA glycosylase | 8 | a,b,g | 6224979 | uracil–DNA glycosylase |
| metabolism | ribonucleotide reduct. large sub. | 24 | a,b,g | 4506749 | ribonucleotide reductase M1 polypeptide |
| ribonucleotide reduct. small sub. | 33 | a,g | 4557845 | ribonucleotide reductase M2 polypeptide | |
| thymidylate synthase | 92 | a-,g- | 15297069 | thymidylate synthetase | |
| dihydrofolate reductase | 141 | g-,b- | 15297069 | dihydrofolate reductase | |
| dUTP pyrophosphatase | S | CCHV ORF49 | 4503423 | dUTP pyrophosphatase | |
| S | SaHV-1 ORF49 | 14756895 | dUTP pyrophosphatase | ||
| thymidine kinase | S | CCHV ORF5 | 11430716 | thymidine kinsae 2, mitochondrial | |
| DNA methyltransferase | S | RaHV-1 54_21 | 4503351 | DNA (cytosine-5-)–methyltransferase 1 | |
| Enzyme | protein kinase | 29 | a,b,g- | 14746991 | serine/threonine-protein kinase PRP4 |
| 40 | a,o | 4505649 | protein kinase cdc2-related PCTAIRE-2 | ||
| 214 | o | 9994197 | G protein-coupled receptor kinase 7 | ||
| S | RaHV-1 54_2 | 14741902 | CamKI–like protein kinase | ||
| phospholipase-like protein | 328 | a- | 5174497 | endothelial cell–derived lipase precursor | |
| b-1,6-N-acetylglucosaminyltransf. | S | BoHV-4 ORF3-4 | 11431963 | glucosaminyl (N–acetyl) transferase 3 | |
| serine protease | S | CCHV ORF47 | 4505577 | paired basic amino acid cleaving system 4 | |
| Gene expression | transcriptional activator | 74 | a | 5174653 | ring finger protein (C3H2C3 type) 6 |
| regulation | bZIP domain | 174 | a- | 4504809 | jun B proto–oncogene |
| Glycoprotein | glycoprotein OX-2-like | 194 | b- | 730246 | OX-2 membrane glycoprotein precursor |
| glycoprotein OX-2-like | 242 | g- | 730246 | OX-2 membrane glycoprotein precursor | |
| Host-virus interaction | TNFR receptor | 13 | HHV-5 UL144 | 4507571 | tumor necrosis factor receptor, member 14 |
| virion–assoc. host shutoff factor | 48 | a | 14738228 | flap structure–specific endonuclease 1 | |
| viral interferon regulatory factor | 89 | g- | 4504723 | interferon regulatory factor 2 | |
| 243 | g- | 13629153 | interferon consensus seq. binding prot. 1 | ||
| S | HHV-8 vIRF-3 | 4505287 | interferon regulatory factor 4 | ||
| G protein-coupled receptor | 27 | b,g- | 13643500 | chemokine (C–C motif) receptor 2 | |
| 248 | b- | 4758468 | G protein–coupled receptor 50 | ||
| S | EHV-2, ORF 74 | 4502639 | chemokine (C–C motif) receptor 5 | ||
| complement binding protein | 10 | g- | 10835143 | decay accelerating factor for complement | |
| viral cyclin | 102 | g- | 14767736 | cyclin D1 | |
| viral interleukin 10 | 140 | g- | 10835141 | interleukin 10 | |
| viral interleukin 6 | 273 | g- | 10834984 | interleukin 6 (interferon, β 2) | |
| viral interleukin 17 | S | HVS-2 ORF13 | 4504651 | interleukin 17 | |
| vBcl-2 | 161 | g- | 4502363 | BCL2–antagonist-killer 1 | |
| 259 | g- | 4557355 | B–cell lymphoma protein 2 α | ||
| 850 | MeHV-1 ORF1 | 11433559 | BCL2-like 10 (apoptosis facilitator) | ||
| MHC I downregulation | 150 | g- | 8923613 | hypothetical protein FLJ20668 | |
| viral FLICE–inhibitory protein | 256 | g- | 14731507 | CASP8 and FADD–like apoptosis regulator | |
| S | EHV-2 E8 | 4505229 | Fas (TNFRSF6)–associated via death domain | ||
| CxC chemokine vIL8 | 531 | a- | 10834978 | interleukin 8 | |
| vMIP-I | 225 | g- | 5174671 | small inducible cytokine subf. A, member 26 | |
| α chemokine | 321 | b- | 4885589 | small inducible cytokine subf. B, member 9B | |
| β chemokine | 387 | b- | 5174671 | small inducible cytokine subf. A, member 26 | |
| vMIP-III | S | HHV-8 K4.1 | 4506829 | small inducible cytokine subf. A, member 17 | |
| signal transduction protein | 316 | RRV, R1 | 12056967 | Fc fragment of IgG, receptor for (CD16) | |
| CARD–like apoptotic protein | 355 | EHV-2, E10 | 4502379 | CARD–like apoptotic protein | |
| U-PAR antigen CD59 | 352 | HVS-2, ORF15 | 13639271 | CD59 antigen p18-20 | |
| natural killer (NK) cell decoy pr. | S | HHV-5 UL18 | 5031745 | major histocompatibility complex, class I, E | |
| colony-stimulating factor I | S | HHV-4 BARF1 | 4885123 | CD80 antigen | |
| C-type lectin-like protein | S | RCMV lectin | 4504883 | killer cell lectin–like receptor subf. C, member 2 | |
| semaphorin homolog | S | AIHV-1 A3 | 4504237 | sema domain, Ig domain, GPI memb. anchor | |
| MHC1 heavy chain | S | RCMV R144 | 9665232 | major histocompatibility complex, class I | |
| Unknown | unknown | 258 | a- | 4504883 | killer cell lectin–like receptor subf. C, member 2 |
| Unknown | S | GaHV-1 UL45 | 4504883 | killer cell lectin–like receptor subf. C, member 2 | |
| Unknown | S | HHV-5 UL1 | 14764567 | pregnancy specific beta-1glycoprotein 5 | |
| Unknown | S | HHV-5 US21 | 6912468 | lifeguard |
[i] HPF: homologous protein family no. S indicates singleton. HPF details can be visualised by searching VIDA by HPF number in http://www.biochem.ucl.ac.uk/bsm/virus_database/VIDA.html(Herpesviridae link).
[ii] a indicates alphaherpesvirus; b, betaherpesvirus; g, gammaherpesvirus; o, other; — only a subset of subfamily members are represented. For singletons, virus abbreviation and gene name are given: CCHV, channel catfish herpesvirus; SaHV-1, salmonid herpesvirus 1; RaHV-1, ranid herpesvirus 1; BoHV-4, bovine herpesvirus 4; HHV-8, human herpesvirus 8; EHV-2, equine herpesvirus 2; HVS-2, saimiriine herpesvirus 2; MeHV-1, meleagrid herpesvirus 1; HHV-5, human herpesvirus 5; HHV-4, human herpesvirus 4; RCMV, rat cytomegalovirus; AHIV-1, alcelaphine herpesvirus 1; and GaHV-1, gallid herpesvirus 1.
[iii] GenBank protein accession no. (GI number). Only the human that hit with the lowest E-value is shown.