Markup | Genome Research

Table 1.

Top 25 Genes More Highly Expressed in AML Than in ALL

Gene description	Probe	Difference	S.E.	Z-score	P-value[ii]	Fold diff[iii]	t-test[iv]	t rank[v]	ut-test[vi]	ut rank[vii]	W. r.s.[viii]	W rank[ix]
Fumarylacetoacetate	M55150	978.04	101.41	9.64	<0.0001	2.21	<0.0001	1	<0.0001	1	0.0146	2
Neuromedin B	M21551	216.62	33.81	6.41	<0.0001	1.94	0.1952	64	0.0025	2	0.0432	7
Leukotriene C4 synthase	U50136	1551.78	253.94	6.11	<0.0001	2.57	<0.0001	2	0.0082	4	0.0584	11
CDC25A Cell division cycle 25A	M81933	178.74	29.31	6.10	<0.0001	3.60	0.0510	38	0.0070	3	0.0678	14
Thrombospondin 1	U12471	128.52	21.94	5.86	<0.0001	1.83	0.0570	39	0.0145	5	0.3275	33
Zyxin	X95735	2587.14	445.32	5.81	<0.0001	7.98	<0.0001	3	0.0199	6	0.0124	1
LYN V-yes-1 Yamaguchi sarcoma viral related oncogene homolog	M16038	1337.77	231.45	5.78	<0.0001	4.49	<0.0001	4	0.0216	7	0.0503	10
Interferon-gamma inducing factor (IGIF)	D49950	167.60	29.25	5.73	<0.0001	3.18	0.0004	7	0.0241	8	0.6428	50
ATP6C Vacuolar H+ ATPase proton channel subunit	M62762	1686.88	300.07	5.62	0.0001	2.33	0.0024	13	0.0322	9	0.4925	43
Metargidin	U41767	481.47	86.18	5.59	0.0002	1.50	0.0049	19	0.0353	10	0.1220	16
Leptin receptor	Y12670	859.65	154.73	5.56	0.0002	3.10	<0.0001	5	0.0414	12	0.0233	3
Ferritin, light polypeptide	M11147	7928.14	1428.69	5.55	0.0002	1.97	0.0799	44	0.0368	11	0.8361	55
HoxA9	U82759	602.71	110.33	5.46	0.0003	3.48	0.0017	12	0.0521	13	0.1409	18
NAB50	U63289	121.53	23.29	5.22	0.0013	n.a.	0.3464	79	0.0955	14	1.0000	>58
Calnexin	D50310	1982.20	385.66	5.14	0.0019	1.47	0.6143	92	0.1184	15	1.0000	>58
PLCB2 Phospholipase C, beta 2	M95678	1281.19	249.67	5.13	0.0020	1.97	0.0147	28	0.1347	16	0.4924	41
Polyadenylate binding protein II	Z48501	4474.14	879.99	5.08	0.0026	1.50	0.5856	90	0.1404	17	1.0000	>58
GTP-binding protein (RAB31)	U59877	398.95	79.87	5.00	0.0041	n.a.	1.0000	>105	0.1772	18	1.0000	>58
Chloride channel (putative) 2163bp	Z30644	760.30	154.08	4.93	0.0056	1.69	0.2998	76	0.2253	19	1.0000	>58
Proteogylcan 1, secretory granule	X17042	5188.71	1060.82	4.89	0.0070	3.82	0.0129	27	0.2738	20	0.8359	53
PPIase, mitochondrial	M80254	377.99	77.41	4.88	0.0073	10.75	0.0015	10	0.2883	22	0.4925	42
CD33	M23197	579.93	119.10	4.87	0.0078	4.25	0.0002	6	0.3060	25	0.0503	9
Activated leucocyte cell adhesion molecule	L38608	119.96	24.71	4.85	0.0084	2.51	0.0488	37	0.2984	23	1.0000	>58
FCGR2B Fc fragment of IgG, low affinity IIb, receptor for (CD32)	X62573	257.44	53.18	4.84	0.0090	1.47	1.0000	>105	0.2835	21	1.0000	>58
Interkeukin-8	Y00787	8645.98	1802.75	4.80	0.0112	9.63	0.0015	11	0.3032	24	0.2158	27

[i] Dataset from Golub et al. (1999).

[ii] P-value computed from Z-score using a modified Bonferroni's correction.

[iii] (n.a.) The mean of one of the groups < = zero.

[iv] P-value obtained from t-test with equivalent variances using a modified Bonferroni's correction.

[v] Relative ranking by significance values obtained from t-test with equivalent variances. >105 indicates that the gene was not ranked because the P-value was 1.0.

[vi] P-value obtained from t-test with unequal variances using a modified Bonferroni's correction.

[vii] Relative ranking by significance values obtained from t-test with unequal variances.

[viii] P-value obtained from Wilcoxon rank sum using a modified Bonferroni's correction.

[ix] Relative ranking by Wilcoxon significance values. >58 indicates that the gene was not ranked because the P-value was 1.0.