Table 1.

Characteristics of the Clones Selected and Their Deletions

Clone no. No.pts % pts with cavitary disease % of contacts with positive tuberculin % of contacts with active disease No.deleted bp No. of DS No. of deleted ORFs
3160[i] 415.428.69.717862425
374350.00.00.031581637
M3061A20.040.00.026481638
97006652313.027.34.222547527
98006082412.534.12.414973320
12542015.027.11.623344427
1209520.025.04.616556323
9802826633.382.45.9375824
17661040.055.72.418916323
2761250.071.40.09236114
M4377A20.010.00.0230813
1006560.09.70.0289013
9802501366.793.85.915817320
1122 19236114
1843 1000
CDC1551§ 80.34.99718614
H37Ra 000
Average13248.42.917.2
2 STD19276.04.124.3

[i] Isolates obtained from the previously reported outbreak: 3160 source case isolated in 1990, a second secondary case was diagnosed seven months later and another case in 1998. The following isolates were included because unusual characteristics: †, Rifampin-resistant with wild-type rpoB gene; ‡, Isoniazid-resistant with catalase-negative phenotype; §, Strain reported to have increased virulence12; , Attenuated variant of sequenced H37Rv strain.

[ii] Pts, patients; bp, base pairs; DS, deleted sequence; ORF, open reading frame; STD, standard deviation.