Example Queries that Cannot be Resolved Accurately by Conventional Querying Systems
| Case type | Source record: DIAN system annotation | |||||
| Identifier | EGAD celluar role | Protein function | Enzyme classification | DoubleTwist biological role | Structure (SCOP) | |
| Annotation | ||||||
| Case 1: Novel gene with no predicted function | UniGene Hs. 104305 | •cell/organism defense •homeostasis •apoptosis •cell division •apoptosis | None | None | •Non-immune cell defense •Apoptosis | •All alpha proteins •DEATH domain •DEATH domain •DEATH domain |
| None | ||||||
| Case 2: Hypothetical gene with predicted function | SWISS-PROT P39959 | •gene/protein expression •RNA synthesis •transcription factors | •DNA or RNA associated proteins | None | •Genome structure and Gene expression •Transcription factors | •Small proteins •Classic zinc finger, C2H2 •Classic zinc finger, C2H2 •Classic zinc finger, C2H2 |
| Putative Zinc Protein | ||||||
| Case 3: Known gene with novel predicted function | UniGene Hs. 2157 | •cell division •apoptosis | •Enzymes •Transferase •Post-translational modifications | •Transferases | •Non-immune cell defense •Apoptosis | •All beta proteins •PH domain-like •PH domain-like •Enabled/VASP homology 1 domain (EVH1 domain) |
|
Wiskott-Aldrich syndrome protein OMIM: 30100 SWISS-PROT: P42768 | ||||||
[i] Three illustrative cases of records that cannot be returned by conventional keyword-based querying systems but that were returned byDIAN are described here.