Allele Frequencies for Chromosome 19 and 13 Loci
| AD Cases | Controls | T-Test CHI-SQ | Pval[i] | ||||||
| Age (S.D.) (n) | 73.4 (10.0) | (210) | 71.3 (5.0) | (159) | |||||
| Marker | Allele | % | (nalleles) | % | (nalleles) | 2.4 | 0.17 | ||
| C19M1 | C | .5227 | (440) | .4968 | (314) | 0.492 | 0.483 | ||
| C19M2 | A | .5959 | (438) | .6195 | (318) | 0.430 | 0.512 | ||
| C19M3 | T | .3144[ii] | (404) | .1429 | (308) | 28.167 | <0.001 | ||
| C19M4 | C[iii] | .3430[ii] | (446) | .1171 | (316) | 50.454 | <0.001 | ||
| C19M5 | C | .9369 | (444) | .9263 | (312) | 0.331 | 0.565 | ||
| C19M6 | A | .4722 | (432) | .4810 | (316) | 0.057 | 0.812 | ||
| C19M7 | A | .2682 | (440) | .2803 | (314) | 0.135 | 0.714 | ||
| C19M8 | A | .2723 | (404) | .2930 | (314) | 0.375 | 0.540 | ||
| C13M1 | C | .4734 | (414) | .4902[ii] | (306) | 0.198 | 0.656 | ||
| C13M2 | C | .4726 | (438) | .5171 | (292) | 1.390 | 0.238 | ||
| C13M3 | A | .4953 | (422) | .4554 | (314) | 1.146 | 0.284 | ||
| C13M4 | C | .4048 | (420) | .4679 | (312) | 2.913 | 0.088 | ||
| C13M5 | A | .5920 | (424) | .5256 | (312) | 3.217 | 0.073 | ||
[i] P values based on χ2distribution.
[ii] Genotypes significantly different from HW proportions at α = 0.05 level.
[iii] Part of APOE-ɛ4 allele determination.