Plasma Lipoproteins and Related Biochemical Variables in Nondiabetic FPLD Family Members According to LMNA R482Q Genotype
| Q482/R482 | R482/R482 | ||||
| with diabetes | without diabetes | ||||
| Number/females | 7/6 | 15/10 | 25/15 | ||
| Definite FPLD (%) | 100 | 66.7 | 0.0 | ||
| Age (years) | 49.1 ± 10.0 | 33.8 ± 15.4 | 39.3 ± 15.4 | ||
| BMI (kg/m2) | 25.2 ± 3.5 | 26.4 ± 4.6 | 26.7 ± 5.4 | ||
| Cholesterol (mmoles/liter) | |||||
| total | 5.90 ± 1.67 | 5.34 ± 0.75 | 5.24 ± 1.17 | ||
| LDL | 2.92 ± 0.31 | 3.54 ± 0.68 | 3.55 ± 1.13 | ||
| HDL | 0.75 ± 0.20 | 1.07 ± 0.20 | 1.32 ± 0.32 | ||
| Triglycerides (mmoles/liter) | 6.65 ± 5.55 | 2.19 ± 1.44 | 1.20 ± 0.60 | ||
| Insulin (U/liter) | 20.8 ± 9.3 | 19.2 ± 13.1 | 10.0 ± 13.1 | ||
| C-peptide (pmoles/liter) | 1219 ± 262 | 977 ± 439 | 610 ± 414 | ||
| Glucose (mmoles/liter) | 8.73 ± 3.00 | 4.94 ± 0.78 | 4.72 ± 0.47 | ||
| Hemoglobin A1C (%) | 7.74 ± 1.25 | 5.68 ± 0.35 | 5.70 ± 0.44 | ||
| Medication use | |||||
| diabetes (%) | 57.1 | 0.0 | 0.0 | ||
| hypertension (%) | 42.9 | 6.7 | 8.0 | ||
| dyslipidemia (%) | 14.3 | 6.7 | 4.0 | ||