Table 1.

Results from Pools and Individual Genotyping of 110 Trios

Marker ΔAIP[i] Pvalues
Peak heights[ii] Individual genotyping[iii]
Not corrected Corrected CLUMP ETDT[iv]
MSX1 10.870.450.300.34
D4S2375 0.90.850.680.75
D4S2374 0.30.340.370.780.68
D4S431 110.750.260.15
DRD5 10.90.760.460.30
D4S1602 0.510.260.120.500.33
D4S3007 0.60.90.90.40.27
D4S230 10.680.150.850.38

[i] Simulated significance levels of the ΔAIP.

[ii] Peak heights method before and after correction for stutter and differential amplification.

[iii] The allele frequencies of probands and controls (the untransmitted alleles) from the true genotyping were analyzed with CLUMP to present a statistical result that is more closely related to the one produced by the peak height method (which uses CLUMP).

[iv] Extended transmission/disequilibrium test (ETDT) from individual genotyping of the families.