BRCA subtype classification using driver modules. (A) Performance accuracy of classifying different subtypes for breast cancer using the activity score of subtype-specific driver modules as features in three distinct data sets. (B) Box plot comparing subtype-specific driver-seeded modules and driver-free modules with respect to three distinct measures: log-rank test P-value, hazard ratio (HR), and concordance index (c-index). (C) A BRCA subtype-specific driver module (BASAL-02) seeded by NCOA3 that distinguished the Basal subtype from rest of the BRCA subtypes. (D) Activity score of the BASAL-02 module across different BRCA subtypes. (E) Kaplan-Meier plot showing the significant association of the BASAL-02 module with patients’ clinical outcome in the three data sets considered.