Overview of HIT'nDRIVE algorithmic framework. (A) HIT'nDRIVE integrates sequence-wise changes in genome with expression changes in transcriptome obtained from patients’ tumor samples. The influence values derived from the protein interaction network indicate how likely a driver gene influences its downstream target genes in the network. (B) The predicted driver genes are used as seeds to discover modules of genes that discriminate between the sample phenotypes using OptDis. (C) Based on this, the driver modules are ranked and thus prioritized.