APOBEC3G clustered mutations are observed across all hominid lineages. An analysis identical to that performed on mutations in the human lineage was used to analyze chimpanzee mutations (from the point of divergence from the human lineage) and lineage-specific mutation sets from modern human and the archaic hominins: Denisovan and Neandertal. All sets contain clusters enriched with mutagenic patterns associated with A3G activity (cluster P < 0.01; one-tailed Fisher's exact test P < 6.8 × 10⁻¹¹). Additionally, mutations common to all three Homo lineages (marked in gray on the phylogenetic tree) also showed evidence of enrichment with a value of 1.40 ± 0.03. The lengths of branches in the phylogenetic tree are not drawn to scale. Error bars represent the standard errors that were calculated using a block bootstrap approach.