Genomic architecture in chemotherapy-naive (n = 62) and chemotherapy-treated (n = 58) samples. (A) Total number of SNVs, (B) total number of indels, (C) average ploidy, (D) percentage of the genome that is amplified (defined as copy number ≥2× the average ploidy), (E) percentage of the genome with deletions (defined as copy number ≤0.5× the average ploidy), and (F) percentage of the genome with LOH. No significant difference between naive and chemo-treated groups is observed in any case. The mean ± 1 SD are highlighted in each case.