LincRNAs are as stable as expression-matched mRNAs. (A) Half-lives of expression-matched lincRNAs (red) and mRNAs (blue) after actinomycin treatment in HUES9 (left) and K562 (right) cells. (B) Nucleotide composition of 7-mers that are depleted in stable mRNAs and lincRNAs in both the 5′ (left) or 3′ ends (right). 7-mers were called as significant at FDR < 0.05 for mRNAs and at P-values <0.05 for lincRNAs, due to their low sample size. (C) Cumulative distribution of half-lives for lincRNAs (left) and mRNAs (right) in HUES9 with and without at least one exon that intersects low complexity repeats. (D) Density of HuR binding sites in different regions of lincRNA (left) and mRNA (right) transcripts.