U2AF65 binding in lincRNAs and mRNAs. (A,B) U2AF65 CLIP-seq binding site density in lincRNAs (left) and mRNAs (right), quantified across the entire gene locus, the processed transcript (exons), and the 3′ and 5′ splice sites. Splice sites were defined as ±50 bp from any splice junction. (C,D) Cumulative distribution of splicing efficiency comparing U2AF65-bound or expression-matched unbound lincRNAs. Study 1 corresponds to data from Zarnack et al. (2013) and study 2 to Shao et al. (2014).