Variation and population genetics. (A,B) Number of SNVs and indels across the MHC region in 50-kb sliding window (step 10 kb). (C) Nucleotide diversity (π) and (D) Tajima's D were calculated in 5-kb sliding windows (step 1 kb). (E,F) Count of nonsynonymous and synonymous SNVs across the MHC region and pN/pS estimated assuming 73% and 27% of sites to be nonsynonymous and synonymous, respectively, calculated as the proportions in the reference pgf haplotype. The MHC classes and important genes, such as classical HLA genes, are marked above.