Insertions and deletions are found nonrandomly within the genome. Results of a permutation test that places identified SVs into the genome at random and determines how frequently the variant overlaps regions of interest. The histograms illustrate the number of intersections between the SV and the given region in 300 runs of the random permutation test, and the dotted line indicates the observed number of intersections. (A) Intersections of deletions (left) and insertions (right) with coding sequence (CDS) regions. (B) Intersections of deletions (left) and insertions (right) with intron regions.