Overview of the breast cancer application. (A) Representative selected gene regulatory network used in the experiment. Larger nodes indicate higher-degree features in the graph. Nodes with a degree ≥30 are labeled. (B) Schematic of miRNA-mediated gene-expression regulation through miRISC. By associating with miRISC, MIR3138 (also known as hsa-miR-3138) targets GNB1 mRNA and reduces translation of the GNB1 protein. (C) One miRNA can target multiple genes, and one gene can be regulated by multiple miRNAs.