UniVI supports cross-modal reconstruction and denoising in CITE-seq. (A,B) Cell type–aggregated marker means for RNA (A) and ADT (B), shown for observed and cross-modally reconstructed profiles (Z-scored per feature across cell types). (C) Stacked test-set latent UMAP colored by reference coarse-level cell types. (D–K) Observed (left) versus cross-modal reconstructions (right) for representative markers: B cells—CD79A (RNA, D), CD19 (ADT, E); mono/mac—LYZ (RNA, F), CD14 (ADT, G); cytotoxic/NK—NKG7 (RNA, H), CD56_1 (ADT, I); T cells—TRAC (RNA, J), CD3_1 (ADT, K). Directions are ADT → RNA (D,F,H,J) and RNA → ADT (E,G,I,K).