The genomic landscape of dnSNVs in natural-born and ART-derived mice. (A) Proportion of dnSNVs that reside in genomic regions assigned to various functional annotations. (B) Proportion of dnSNVs in natural and ART genomes assigned to “modifier” and “low” functional effect predictions. (C) The percentage of dnSNVs overlapping TE repeat classes in the two breeding cohorts. We find no significant cohort-level differences in dnSNV enrichment in any of these annotation categories.