RECOMBINE identifies concise discriminant markers of cell types across human tissues. (A) Schematic of the tissues profiled by single-cell RNA sequencing from the Tabula Sapiens data set used in this study. (B) Workflow of RECOMBINE applied to the Tabula Sapiens to identify recurrent composite markers that effectively discriminate cell types in all tissues. (C) UMAP projections of pseudobulk expression of RECOMBINE markers across cell types in all tissues, colored by cell lineage (left) and tissue type (right). (D) Heatmap showing pseudobulk expression of RECOMBINE markers across cell types in all tissues.