Comparison of AUPR measures between the adapted ContrastiveVI (variant 1 and 2), MultiMIL, HiDDEN, and scPSS (our method) for predicting healthy and damaged cells, using pre-MI (myocardial infarction) data set as reference and cells collected at different time points after MI as query data set
| Query data set | Adapted ContrastiveVI (Variant 1) | Adapted ContrastiveVI (Variant 2) | HiDDEN | MultiMIL | scPSS (Ours) |
|---|---|---|---|---|---|
| 1 h | 0.5369 ± 0.0747 | 0.4562 ± 0.0117 | 0.3801 ± 0.0000 | 0.6230 ± 0.0346 | 0.8426 ± 0.0033 |
| 4 h | 0.8635 ± 0.0552 | 0.6230 ± 0.0132 | 0.6685 ± 0.0000 | 0.9597 ± 0.0038 | 0.9591 ± 0.0004 |
| Day 1 | 0.9074 ± 0.0109 | 0.7169 ± 0.0097 | 0.6494 ± 0.0000 | 0.8782 ± 0.0254 | 0.9591 ± 0.0002 |
| Day 3 | 0.5099 ± 0.0405 | 0.4875 ± 0.0157 | 0.4238 ± 0.0000 | 0.7219 ± 0.0282 | 0.8944 ± 0.0011 |
| Day 7 | 0.5676 ± 0.0282 | 0.6009 ± 0.0069 | 0.5957 ± 0.0000 | 0.5611 ± 0.0408 | 0.8239 ± 0.0040 |
| All post-MI | 0.8088 ± 0.0374 | 0.7306 ± 0.0102 | 0.6825 ± 0.0000 | 0.7609 ± 0.0367 | 0.9024 ± 0.0003 |
[i] Results show mean ± 95% confidence interval from 25 independent runs. For each setup, the best result is highlighted in bold.