Comparison of AUC measures between the adapted ContrastiveVI (variant 1 and 2) models, MultiMIL, HiDDEN, and scPSS (our method) for predicting healthy and damaged cells, using pre-MI (myocardial infarction) data set as reference and cells collected at different time points after MI as query data set
| Query data set | Adapted ContrastiveVI (Variant 1) | Adapted ContrastiveVI (Variant 2) | HiDDEN | MultiMIL | scPSS (Ours) |
|---|---|---|---|---|---|
| 1 h | 0.6664 ± 0.0706 | 0.5801 ± 0.0128 | 0.5031 ± 0.0000 | 0.7809 ± 0.0428 | 0.9176 ± 0.0015 |
| 4 h | 0.8295 ± 0.0670 | 0.5027 ± 0.0201 | 0.5977 ± 0.0000 | 0.9328 ± 0.0091 | 0.9403 ± 0.0006 |
| Day 1 | 0.8974 ± 0.0089 | 0.6474 ± 0.0129 | 0.6432 ± 0.0000 | 0.8444 ± 0.0325 | 0.9509 ± 0.0002 |
| Day 3 | 0.6372 ± 0.0375 | 0.5824 ± 0.0162 | 0.5396 ± 0.0000 | 0.8479 ± 0.0236 | 0.9322 ± 0.0006 |
| Day 7 | 0.6413 ± 0.0271 | 0.6668 ± 0.0060 | 0.6929 ± 0.0000 | 0.6181 ± 0.0506 | 0.8511 ± 0.0027 |
| All post-MI | 0.8114 ± 0.0350 | 0.7281 ± 0.0110 | 0.7359 ± 0.0000 | 0.7990 ± 0.0413 | 0.9012 ± 0.0004 |
[i] Results show mean ± 95% confidence interval from 25 independent runs. For each setup, the best result is highlighted in bold.