Methods for integrating and extrapolating single-cell time-series data
| OT | ODE | AE | OT/ODE+AE | Graph | Multimodal OT | Sunbear | |
|---|---|---|---|---|---|---|---|
| Optimized in the original data space | ✓ | ✓ | ✓ | ||||
| Learns from distal time points | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |
| Does not require cell-type labels | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | |
| Corrects for batch effects | ✓ | ||||||
| Models multimodal data | ✓ | ✓ | |||||
| Performs imputation on missing conditions | ✓ | ✓ | ✓ | ||||
| Performs imputation on missing modalities | ✓ |
[i] (OT) Optimal transport, (ODE) ordinary differential equations, and (AE) autoencoder.