Table 2.
Transcription factor binding site motifs enriched in active enhancers
| Motif consensus sequence | P-value | % of targets | % of background | Known motif | |
|---|---|---|---|---|---|
| Panel 1 |  | 10−61 | 29.98% | 9.36% | JUNB(bZip) |
 | 10−29 | 5.22% | 0.48% | TP53 | |
 | 10−21 | 17.72% | 7.53% | MITF | |
 | 10−17 | 33.01% | 20.21% | SOX10 | |
| Panel 2 |  | <10−100 | 13.05% | 0.75% | YY1 |
 | <10−100 | 23.93% | 4.96% | ELK1(ETS) | |
 | <10−100 | 7.03% | 0.73% | THAP11 | |
 | <10−100 | 14.56% | 4.16% | SREBF2 | |
 | <10−100 | 7.73% | 1.70% | ZNF143 | |
 | 10−95 | 9.46% | 3.32% | NRF1 | |
 | 10−90 | 10.2% | 3.87% | JUNB(bZip) | |
 | 10−74 | 1.97% | 0.16% | ZBTB33 | |
 | 10−58 | 2.23% | 0.32% | TP53 |
[i] The “% of targets” column indicates the percentage of active enhancers from our CapSTARR-seq assay that contain each motif. The “% of background” column indicates the percentage of regions from our CapSTARR-seq assay that did not show enhancer activity and contain each motif (see Methods). The “known motif” column indicates the transcription factors known to bind to the given motif sequence. Reported P-values are from HOMER (Heinz et al. 2010) and calculated using a hypergeometric distribution P-value test.