Distribution of bla_KPC-harboring plasmids and non-bla_KPC-harboring plasmids across ST258 clades. Phylogenetic trees for isolates belonging to (A) clade A1 and (B) clade A3, with corresponding distribution of bla_KPC, Tn4401 subtype, and CRE plasmid cluster as shown previously, as well as results of MOB-clustering analysis including both bla_KPC-harboring and non-bla_KPC-harboring plasmids.