The performance of DeltaSplice and baseline methods in predicting splicing-altering mutations as measured by reporter assays. (A) The distribution of ΔPSI measured by RNA-seq and predicted by each method is shown for SNVs in Vex-seq data set. (B) Top k accuracy of DeltaSplice and baseline methods on MFASS data set. Splicing-disrupting variants (SDVs; which have ΔPSI_alt-ref < −0.5) were used to calculate top k accuracy with varying k. The inset shows the top k accuracy with k = 1048 (the true number of SDVs in the data set). (C) Similar to B, but only for variants ≥20 bp from the nearest splicing sites.