Summary of the number of differentially active pathways in each glioblastoma metamodule, according to the four tested methods
| SiPSiC | AUCell | ssGSEA | VAM | Overlap | |
|---|---|---|---|---|---|
| AC-like | 4 | 13 | 10 | 1 | 1 |
| MES-like | 23 | 20 | 17 | 28 | 13 |
| OPC-like | 2 | 2 | 10 | 0 | 0 |
| NPC-like | 8 | 6 | 4 | 13 | 2 |
| Missed | 0 | 3 | 5 | 5 | — |
[i] Missed pathways are cases in which the relevant method failed to detect differential activity of a given pathway in the specific cell group where all other methods detected the pathway. For a summary of the analysis of all 50 hallmark pathways, see Supplemental Table S4.