Characterization of conserved module clusters. (A) Prognostic significance and biological functions of pan-cancer conserved module clusters. The heatmap shows the hazard ratios of module clusters in at least three cancer types. The module clusters were annotated based on the most frequent GO process. (B) Aggregated networks of the top eight module clusters with the highest prognostic frequency in multiple cancers. The top 20 nodes with the highest connectivity are labeled. (C) Enrichment of module clusters in chromosomal cytobands. The heatmap illustrates the number of cancer types in which the module clusters show enrichment in the cytobands. The top 10 module clusters with the highest frequency of enrichments are shown.