The global structural comparison suggests an archaeal origin of core proteins relating to information storage and processing. (A) Gene overrepresentation analysis for proteins with a structural homolog found in M. jannaschii only. For the list of proteins used for the overrepresentation analysis, see Supplemental Table S7. (B–G) Distribution of the structural conservation scores for protein-coding genes in the selected gene sets upon comparing H. sapiens to E. coli, Caulobacter vibrioides NA1000, M. jannaschii, Candidatus Prometheoarchaeum syntrophicum, or Candidatus Lokiarchaeum sp. GC14_75. Violin plots were used to represent the distribution of the structural similarities, with the name of the gene set marked at the top of each panel. The three dashed lines represent 25% quartile, median value, and 75% quartile. For the lists of genes in the gene sets, see Supplemental Table S5.