Highlighting species-specific features using the comparative browser. (A) Lineage-specific epigenomic innovation. H3K27ac, NR2F1 ChIP-seq data from both human and chimpanzee CNCCs in SMAP2 gene (annotated in human only) regions were plotted in the WashU Comparative Epigenome Browser. A human-specific NR2F1 and H3K27ac peak suggests a putative human-specific enhancer in this region. The putative enhancer is associated with a human-specific NR2F1 binding motif. (B) 3D genome structure differences between species. A human lymphoblastoid Hi-C contact map mapped to hg38 and gorilla lymphoblastoid Hi-C data mapped to gorGor4 were compared by anchoring to the human–gorilla alignment track.