Disease annotation of hybridization-induced dysregulated genes. The expression patterns of disease-related hybridization-dysregulated genes in X. maculatus (X. mac), X. couchianus (X. cou), X. hellerii (X. hel), and interspecies hybrids (Hyb) are presented using a heatmap (left). Colors represent gene expression levels, with gray meaning “not appliable.” Names of each gene are color-coded (red indicates X. mac–X. hel hybrids; dark gray, X. mac–X. cou hybrids; blue, X. cou–X. hel hybrids). The dysregulated genes’ associations to diseases are plotted on the right. A yellow block means a gene is not associated to a disease type, and a blue block means a gene is associated to a disease type. Asterisks highlight examples of human disease–relevant genes that are dysregulated in Xiphophorus hybrids.