Overview of longitudinal sample collections for personal exposome and multi-omics profiling. (A) Personal exposome characterized by the exposometer includes environmental factors, biological components, and chemical stressors. Internal multi-omes include the gut microbiome, metabolome, proteome, toxins and carcinogens, cytokines, and blood tests. (B) The amount and collection time of each type of multi-omics and exposome samples. (C) Sample distribution and constitution of the exposome and internal multi-omics for monitoring precision environmental health.