SORL1 has a signal region identified in the ADSP WES discovery data set (A) and replicated in the ADSP validation data set (C) but not in the ADSP WGS replication data set (B). The signal cluster is identified in the POKEMON test with the DBSCAN algorithm. All variants within the clusters are rare variants with MAF < 0.05. Clusters classified as case clusters are formed by variants carried primarily by AD subjects and clusters classified as control clusters are formed by variants carried primarily by cognitively normal subjects. Variants assigned with a cluster label are shown, but all the other variants are not shown in the figure.