Disease gene importance scoring process and scoring results across patients. (A) The individualized disease gene importance (IDGI) scoring pipeline begins with the accessing the baseline parameters of the individualized disease modules. Next the disease gene is scored, and the shortest paths associated with the disease genes are removed from the individualized disease module. The change in parameters is then quantified into the IDGI score. (B) Boxplots showing the distribution of IDGI scores for each patient. High IDGI scoring genes (outliers) are colored to show rare (<5% mutated in TCGA BC) and frequent mutations (>5% mutated in TCGA BC).