MEIs discovered in this study. (A) MEIs that we discovered are broken down by population and MEI type. At the top (labeled “Merged”), 104,350 nonredundant MEIs were discovered. (B) A comparison of our study with three other published MEI discovery projects (1KGP LC, GTEx, and gnomAD-SV) (Sudmant et al. 2015; Cao et al. 2020; Collins et al. 2020, respectively). The four-way Venn diagram comparing these studies with our data set indicates that 65,192 (or 62.3%) of our MEIs are novel. All these MEI discovery studies were performed with MELT.