BrainSpan data completion and imputation evaluation. (A) CANDECOMP/PARAFAC (CP) tensor decomposition framework. (B) The schematic diagram of leave-one-out (LOO) imputation evaluation strategy. Gray boxes represent missing values. Yellow boxes represent one leave-out sample, assuming all gene expression values in that column are not available. X-axis, y-axis, and z-axis correspond to individuals, brain regions, and genes, respectively. (C) R² of imputation performance of BrainSpan data sets by LOO strategy. (D) One example showing the correlation between observed and predicted gene expression.