Combined organ protein networks modulated by microbial colonization. Proteins significantly increased in either GF or conventional animals were analyzed for interactions through STRINGdb. Edges in each node represent the combined score accounting for all interaction sources. The edges are sized by the combined score, with the minimum threshold being 0.8 (of a maximum confidence 1). Nodes represent gene names of proteins with a highly ranked association (a minimum statistical cutoff of |π| > 1) within at least one organ. Nodes are sized by the number of organs with which the protein had a strong association. The level of association of each node to a particular organ is colored according to the fraction of the total |π|-score each organ contributes. Below each node is a bar plot of the π-scores for each organ within the node. Putative functional groupings within the network are highlighted. Select sections are highlighted in colored boxes and shown in 2× zoom.