Ages of cancer diagnosis and parental ages in DNM and FM carriers. (A) Ages of cancer diagnosis for all patients. The x-axis represents types of different cancer types. Cancers were classified by site: LFS spectrum (osteosarcomas, soft-tissue sarcomas, breast, brain, adrenal, lung cancers, and leukemia) and non-LFS spectrum (prostate, colon, kidney, or thyroid cancers, and others). The green dots are for females, while the blue dots are for males. (B) Distribution of paternal ages. (C) Distribution of maternal ages. All solid dots represent the DNM carriers.