Illustration of clinical counseling using Famdenovo based on family history. The number below each individual is the age at last contact (healthy or affected with cancer). The arrow points to the counselee who is known to be a TP53 mutation carrier. The de novo probabilities shown are given by Famdenovo.TP53. (A) A pedigree with four cancer patients. (B) A pedigree with three cancer patients. (C) A pedigree with two cancer patients.