Mutation accumulation in predicted NER-deficient and NER-proficient breast cancer whole-genomes. (A) Relative contribution of each indicated context-dependent base substitution type to the average 96-channel mutational profiles of NER-deficient and NER-proficient breast cancer samples. (B) Number of Signature 8 mutations in NER-deficient and NER-proficient breast cancer whole-genomes (n = 27 and n = 43, respectively). Asterisk indicates significant difference (P < 0.05, Wilcoxon rank-sum test).