Feature importance for XCI/escape and silencing dynamics model. For each model, features are ranked class-wise according to their importance for the classification, quantified by the Mean Decrease in Accuracy (MDA) (Methods). (*) The top features of each class (10 for XCI/escape model; 8 for silencing dynamics model) that are used to build the final model. For more details, see Supplemental Figure S3. Similar results are obtained from the XCI/escape model trained on undifferentiated mRNA-seq data (Supplemental Fig. S20; Supplemental Text S8).