Distribution of functional coding variants across LGALSL and PKP4. The distribution of LGALSL (A) and PKP4 (B) coding variants across domains (LGALSL transcript ENST00000238875 and PKP4 transcript ENST00000389757). The y-axis corresponds to the total number of variants identified at a specific location. The blue boxes highlight the (A) LGALSL carbohydrate-binding domain and (B) PKP4 armadillo repeat domain 2 (ARM2) found to be enriched for variants in cases (green) compared to controls (black). Each domain's OE-ratio percentile is marked above for both tolerant (bright blue) and intolerant (orange) domains.